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August 3, 1940

GRANULOMATOUS TUMOR FOLLOWING INTRAMAMMARY INJECTION OF COLLOIDAL THORIUM DIOXIDE

JAMA. 1940;115(5):363-364. doi:10.1001/jama.1940.72810310004007b
Abstract

Recent studies in the roentgenographic demonstration of tumors of the breast after injection of the ducts with an opaque medium have aroused considerable enthusiasm. It is not generally appreciated, however, that this diagnostic procedure may produce untoward reactions of considerable moment.

Mammography was first suggested by Ries,1 of Chicago, who in 1930 reported one case in which iodized poppyseed oil was injected intraductally. This was unfortunately followed by abscess formation. No other studies of similar nature were made by any one until 1937, when Hicken and his associates2 reported the use of this method in fifty-six cases, using colloidal thorium dioxide in most instances. Hicken's study suggested that by this method it might be possible to differentiate localized from infiltrating growths, solid from cystic tumors, and simple retention cysts from cystic degeneration of the breast. He felt that it was especially valuable in determining the location, number and

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