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This pamphlet, issued under the authority of the Federal Security Agency of the United States Public Health Service, reviews the available medical literature dealing with addiction to codeine and then reports some studies on this subject carried out at Fort Leavenworth, Kan., and at Lexington, Ky. A third part is devoted to a study of the effects of codeine on the electrical potentials of the cerebral cortex. Part four concerns the effects of codeine addiction on behavior; part five, the urinary excretion of codeine; and part six, the use of codeine for the control of tuberculous cough. The final portion of this report is on the significance of codeine as an addicting drug.
It seems to be well established that codeine has an addiction liability, even though the amount of codeine required to satisfy and support a preestablished addiction to morphine is 5.2 times greater. The evidence seems to indicate
Studies on Codeine Addiction. JAMA. 1940;115(5):409-410. doi:10.1001/jama.1940.02810310067036