Malaria is being used more and more in the treatment of resistant syphilis of the central nervous system as well as of dementia paralytica. This form of fever treatment has established its value in spite of the definite risk associated with it, even in selected cases. For this reason there is a growing need for some means of management of therapeutic malaria. Thus, if some agent were at hand to cause a temporary interruption in the course of the fever for even forty-eight hours, there would be an opportunity for the patient to recover from the effects of the fever. The cycle might then be allowed to continue until sufficient hours of hyperpyrexia had been accomplished.
In 1937 Fong1 reviewed the literature on malaria mortality and reported eleven series of cases, totaling 13,267 patients. In this group, in part unselected, the mortality was 7.51 per cent. The usual causes
COLE HN, DeOREO GA, DRIVER JR, JOHNSON HH, SCHWARTZ WF. USE OF BISMUTH INJECTIONS TO MANAGE COURSE OF THERAPEUTIC MALARIA. JAMA. 1940;115(6):422-427. doi:10.1001/jama.1940.02810320002002