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The author presents in this monograph an account of investigations made in the Küstensanatorium Apelviken, Varberg, on the importance of vitamin C in the treatment of tuberculosis. He studied various methods of determining vitamin C deficiency, such as the capillary resistance test and various chemical methods for the estimation of ascorbic acid in the blood serum and in the urine. The amount of reduced ascorbic acid in the blood serum is a significant index of the condition of the patient. In 326 healthy persons an average value of 0.22 mg. of ascorbic acid per hundred cubic centimeters of serum was found early in the year and 0.90 mg. per hundred cubic centimeters of blood serum in late summer. In 225 tuberculous patients the values were less, being 0.10 and 0.48 mg. per hundred cubic centimeters of blood serum respectively. It was concluded from these studies that a tuberculous patient needs
Ascorbinsäurestudien an Gesunden und Tuberkulosekranken. JAMA. 1940;115(6):483. doi:10.1001/jama.1940.02810320063034