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December 9, 1950

Simmonds' Disease: Extreme Insufficiency of the Adenohypophysis

JAMA. 1950;144(15):1322. doi:10.1001/jama.1950.02920150096051

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This is a valuable monograph. The pathogenesis and pathology are completely and clearly developed. The far reaching effects of this condition on the other endocrine glands and the viscera are discussed in some detail. The clinical course of the disease is thoroughly reviewed. Therapy is given only general discussion, with suggestions for substitution therapy for hypogonadism, hypoadrenalism and hypothyroidism. The advent of potent tropic hormones, such as the adrenocorticotropic and thyrotropic hormones, and their influence on therapy is not mentioned.

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