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August 17, 1940

LYMPHOGRANULOMA VENEREUM IN RELATION TO CHRONIC ULCERATIVE COLITIS

JAMA. 1940;115(7):515-519. doi:10.1001/jama.1940.02810330021008
Abstract

In 1928 Frei and Koppel1 first suggested, on the basis of clinical evidence, that esthiomene and inflammatory rectal stricture might result from lymphogranuloma venereum. Frei attributed the lesions to lymph stasis with possible banal secondary influences. Experimental evidence rapidly accumulated, however, to indicate that the genito-anorectal syndrome was a manifestation of the presence of the virus of lymphogranuloma venereum itself. This evidence has taken three main forms: (1) microscopic studies, (2) preparation of skin test antigens from the exudates of the affected tissues (Nicolau and Banciu,2 Nicolas and his co-workers,3 Wien and Perlstein4), and (3) direct isolation of the virus from the tissues in susceptible experimental animals, usually the guinea pig and monkey (Levaditi and his co-workers,5 Travassos,6 Caminopetros7). In addition to the experimental evidence, so large a mass of clinical evidence has accumulated in recent years that rectal stricture with or without

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