During the past two decades the widespread therapeutic use of malaria gave rise to the consideration of other pyrexial methods for the treatment of paresis. The present study has been designed to compare the therapeutic results obtained by use of artificial fever produced by physical methods with those obtained by the use of inoculated malaria in the treatment of paresis. These two methods of fever therapy were employed independently or in association with some form of chemotherapy and have been evaluated in terms of the clinical and serologic response observed in the patients. The effects of chemotherapy alone have not been evaluated.
A total of 1,420 patient records were pooled for this study. Of these, 1,100 patients were treated with malaria and 320 with artificial fever.Prior to the administration of fever therapy, the diagnosis of paresis or of taboparesis was established for each patient. In evaluating the
O'Leary PA, Bruetsch WL, Ebaugh FG, Simpson WM, Solomon HC, Warren SL, Vonderlehr RA, Usilton LJ, Sollins IV. MALARIA AND ARTIFICIAL FEVER IN THE TREATMENT OF PARESIS. JAMA. 1940;115(9):677-681. doi:10.1001/jama.1940.02810350021006