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December 16, 1950

The Diagnosis of Salmonella Types

JAMA. 1950;144(16):1411. doi:10.1001/jama.1950.02920160085031

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Diarrhea, typhoid and paratyphoid fevers, food poisoning, bacteremia, bone infections and even infections of the central nervous system are manifestations of the pathogenicity of the Salmonella group in man. The organisms are also found in rodents, horses and birds, including chickens. Differentiation of typhoid from paratyphoid fever and the incrimination of the agents responsible for gastroenteritis caused by Salmonella necessarily are dependent on isolation and identification of the organisms. Salmonella typing has considerable epidemiological value. Immunologic differentiation of these organisms has been emphasized since the 1920's; prior to that time they were separated on the basis of physiological characteristics. An absurd number of new species have been described solely on the basis of immunologic differences; it now appears more logical to subdivide the serotypes into biochemical types by biochemical methods, and this is the author's approach. This handbook incorporates details of methods for preparing antigens, vaccines and immune serums, performance

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