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Gye, director of the Imperial Cancer Research Fund, reports that a large part of the cancer research concerns the induction of malignant new growths by application of pure chemical substances and points out that this aspect of carcinogenesis has occupied the attention of the scientific staff of the fund for several years. Pullinger has found that polycyclic hydrocarbons which have the property of inducing cancer evoke, on the second to the fourth day after application, a reaction which is characteristic and may be specific. The chemically related hydrocarbons which do not induce cancer formation do not evoke the reaction. Crabtree's experiments indicate that substances with the biochemical property of inhibiting cell glycolysis can, under different experimental conditions, either retard or accelerate the rate of induction of tumors by carcinogenic hydrocarbons.
The original observations of Cramer and Horning that brown degeneration of the adrenals occurs in mice which have been subjected
Thirty-Seventh Annual Report 1938-1940 of the Imperial Cancer Research Fund. JAMA. 1940;115(14):1222. doi:10.1001/jama.1940.02810400074033