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October 19, 1940


JAMA. 1940;115(16):1396. doi:10.1001/jama.1940.02810420082032

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The work of Wright on therapeutic immunization opened up a new field in the application of blood transfusion. Immunotransfusion, or transfusion of blood from donors previously prepared by vaccination, has had sporadic trials but soon fell into disuse because of more or less disappointing results. The problem was complicated by a multitude of factors involving varying effects of vaccination on the donor, the immunobiologic status of the patient, its modification by the disease and, finally, the effect on it of the transfused blood. The present volume is the result of a six year study carried out by the author in the Ukrainian Institute of Experimental Medicine (direction of Professor Shamov). The effects of active antigens were studied in animal experiments. Determination of immunobiologic indexes of the blood of the recipient was made in the clinical material, comprising 127 patients and 243 transfusions. The effect of transfusion was evaluated in each

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