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December 28, 1940

Current Comment

JAMA. 1940;115(26):2285. doi:10.1001/jama.1940.02810520047015

PLASMA IN TREATMENT OF ACUTE HEMORRHAGE  The present World War has enormously stimulated studies on effective substitutes for blood transfusion in treatment of hemorrhage. Recently Buttle and his co-workers1 from the Department of Physiology, Middlesex Hospital, reported an evaluation of various blood substitutes based on controlled experiments in animals. As a result of their work they placed the substitutes in the following order of therapeutic value: (1) plasma, (2) serum, (3) hemoglobin-Ringer, (4) "gum-saline," (5) red cells suspended in "crystalloid" solution, and (6) physiologic solution of sodium chloride or isotonic dextrose solution. By way of practical accord with these conclusions, Aylward and his colleagues2 working in Manchester report careful laboratory investigations on the technic of the concentration and drying of plasma. The dried product has several important advantages: stability, economy of storage place, ease of transport, and facility in the preparation of concentrated plasma—the latter arising from the

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