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January 13, 1951


Author Affiliations

National Institutes of Health, Bethesda 14, Md.

JAMA. 1951;145(2):106. doi:10.1001/jama.1951.02920200046021

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To the Editor:—  Johansen and Erickson, in their article entitled "Current Status of Therapy in Leprosy" in The Journal (144:985 [Nov. 18] 1950), give adequate information by reference or otherwise as to the origin and source of the compounds they used, except 4-amino,4′-beta-hydroxy-ethylaminodiphenylsulfone (HES). This compound was synthesized, studied and tested for activity in experimental tuberculosis for the first time in the laboratories of the National Institutes of Health by my associates and me (Smith, M. I.; Jackson, E. L.; Junge, J. M., and Bhattacharya, B. K.: Am. Rev. Tuberc.60:62 [July] 1949; Smith, M. I.; Jackson, E. L., and Bauer, H.: Ann. New York Acad. Sc.52:704 [Dec.] 1949). The compound was generously supplied by Merck & Company, Inc., through Dr. Augustus Gibson, who offered to make it in sufficient quantity to be available for clinical tests in tuberculosis and leprosy. The work on tuberculosis has

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