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February 24, 1951

INSULIN AND FAT FORMATION

JAMA. 1951;145(8):566. doi:10.1001/jama.1951.02920260034013
Abstract

Indications of a relation between insulin, or more specifically a lack of insulin such as occurs in diabetes mellitus, and fat metabolism were observed many years ago. The hyperlipemia, ketosis and ketonuria of the diabetic may be cited as well known examples, and each may be interpreted as evidence of an impairment in the metabolism of fat, perhaps related to a lack of insulin. Indeed, over 30 years ago several clinical authorities,1 observed that patients with diabetes mellitus fared better on a high fat diet than on high protein or normal diets. Similar results were obtained experimentally only a few years ago in rats made diabetic by alloxan2; furthermore, rats made diabetic by pancreatectomy show a distinct preference for fat if allowed a "free choice" diet.3 The symptoms of diabetes were absent in each case as long as the animals were allowed the high fat ration. One

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