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April 7, 1951

CONGENITAL HEMOLYTIC ANEMIAREPORT OF FOUR CASES IN ONE FAMILY

Author Affiliations

Gary, Ind.

JAMA. 1951;145(14):1065-1067. doi:10.1001/jama.1951.72920320001011
Abstract

The purpose of this paper is to present an interesting family pedigree of four generations in which familial hemolytic anemia or jaundice was present.

The grandmother of Mrs. K. died at the age of 23 years from "complications of an enlarged spleen and yellow jaundice." A sister of the grandmother also died of yellow jaundice in the fifth decade. The two parental relatives (father and his sister) both had enlarged spleens and frequent clinical attacks of jaundice and anemia. The father of Mrs. K. is still living at age 63, but his sister died at 33 years of age of "complications of yellow jaundice." We were indeed fortunate to obtain a complete blood count from Mrs. K.'s father on March 28, 1950. It was he who was instrumental in delaying surgery on his only child (Mrs. K.) and his three granddaughters until they were desperately ill. The following is the

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