Physicians treating tuberculosis appreciate the worsening of the patients' prognosis when the larynx becomes involved. The poor results of treatment heretofore are also well known.1 Opinion would fluctuate between enthusiasm for some form of local treatment and a pessimistic outlook: the feeling that the only means of treating the larynx was by improvement in the pulmonary disease.
In 1946 Figi and Hinshaw2 reported the beneficial effect of streptomycin in four cases of tuberculosis of the larynx. A number of studies3 since then have confirmed their findings. As a result the treatment and prognosis of this disease have been completely revolutionized.
One hundred and twenty four patients with tuberculosis of the larynx treated with streptomycin and/or paraaminosalicylic acid (PAS) have been studied at the Hines Hospital and the Chicago Municipal Tuberculosis Sanitarium. Transfer, death or inadequate follow-up made critical evaluation impossible in many cases. Seventy patients who were
Wallner LJ, Turner GC, Lichtenstein MR, Sweany HC. TREATMENT OF TUBERCULOSIS OF THE LARYNX BY CHEMOTHERAPY. JAMA. 1951;145(16):1252–1254. doi:10.1001/jama.1951.02920340030009