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May 19, 1951


JAMA. 1951;146(3):260. doi:10.1001/jama.1951.03670030038016

Segal and his associates recently described a test for determining the presence or absence of free hydrochloric acid in the stomach without subjecting the patient to intubation.1 The principle of the test lies in the use of a cation exchange resin to which is attached a special indicator cation that can be readily identified when it is released from the compound by an ion exchange reaction. Clinical trials have been based on administration of a quininium exchange indicator compound prepared by subjecting an acid-conditioned cation exchange resin to a solution of quinine hydrochloride. By this treatment, quinine replaces the hydrogen cations of the carboxylic acid groups present in the resin. If free hydrochloric acid is present in the stomach, the quinine will be replaced by hydrogen ions and the liberated quinine will be absorbed into the body and can later be detected in the urine. Smaller amounts of quininium

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