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May 26, 1951

PREPARATION OF AN ULTRAFILTRABLE ACTH, EFFECTIVE IN SMALL DOSES

Author Affiliations

Institute of Biochemistry, University of Bologna, Bologna, Italy.

JAMA. 1951;146(4):396. doi:10.1001/jama.1951.03670040096031

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Abstract

To the Editor:  —An ultrafiltrable preparation of adrenocorticotropic hormone, effective clinically in daily doses of only 3.5 to 7 mg., has been prepared. This preparation has been used successfully in total doses not exceeding 60 to 80 mg. in the treatment of rheumatoid arthritis, purpura annularis telangiectodes (Majocchi's disease), lupus erythematosus and certain ophthalmologic conditions. No toxic manifestations have as yet been noted. A dose of 3 mg. induces a fall in eosinophils in persons with normal adrenal functions, according to Thorn's technique. The preparation is obtained by ultrafiltration of an aqueous solution of anterior pituitary powder buffered at pH 5.2. It is slightly yellow and thermostable and contains about 2.5 mg. of solid substance per milliliter. The nitrogen content is about 5 per cent of the organic substance. Amino acid analysis by paper chromatography reveals a limited number of amino acids, including aspartic acid, glutamic acid, tyrosine, glycine and

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