Hypoglycemia may be brought about by several conditions, among which are various glandular conditions. There is hyperinsulinism as a result of islet cell tumor of the pancreas, the hypoglycemia due to Simmonds' disease of the pituitary, and hypoglycemia due to myxedematous condition of the thyroid. In addition, we have the hypoglycemia due to liver dysfunction, and the functional hypoglycemia which is considered to be on an emotional basis.
However we shall not consider these hypoglycemias here. We shall concern ourselves only with the so-called hypoglycemic reactions produced by the giving of exogenous insulin in the treatment of diabetes mellitus.
In all the previous mentioned hypoglycemias we start with a normal or below-normal fasting blood sugar. The glucose tolerance curve is either flat or below normal with one exception—the glucose tolerance curve of liver dysfunction. In that condition the curve bears a resemblance to a diabetic curve in certain features, but
Benjamin S. HYPOGLYCEMIC REACTIONS TO INSULIN. JAMA. 1951;146(9):813-814. doi:10.1001/jama.1951.03670090045013