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June 30, 1951


JAMA. 1951;146(9):819-820. doi:10.1001/jama.1951.03670090051019

Disseminated lupus erythematosus is a prolonged febrile disease which may superficially resemble rheumatic fever and rheumatoid arthritis. The diagnosis may be extremely difficult in the absence of cutaneous manifestations. Hargraves, Richmond, and Morton1 observed in bone marrow preparations two types of cells which have not been previously described. One cell, which they designated as a "tart" cell, appears to be a histiocyte or a monocytoid reticuloendothelial cell that contains a second characteristic nucleus within the Hof of the primary nucleus. This cell was found in practically all bone marrows. It was present in increased numbers in bone marrow preparations from patients with lymphoblastoma, pulmonary infection, or metastatic carcinoma. The second cell described was referred to as an "L. E." cell and was found in the bone marrow only in patients with acute disseminated lupus erythematosus. The L. E. cell is a mature neutrophilic polymorphonuclear leukocyte, which differs from the

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