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To the Editor:
—Your editorial on "Schedules of Antibiotic Administration" in the April 21 number of The Journal appears to me to be confusing and to neglect consideration of most important evidence available on the subject. I cannot agree that any uncertainty as to the most effective dosage schedule of antibiotics will be resolved by conclusive information "as to whether the mechanism of their action in vivo is the same as that in vitro or whether host factors may supervene to augment and to supplement their direct bactericidal effect." Neither do I follow the reasoning that leads to the conclusion that "the concentration of penicillin at the focus of infection should probably be maintained at the maximally effective level" (italics mine). Instead of attempting to solve the problem of the most effective dosage schedule of penicillin by speculation and reasoning from extraneous data as to its action in vitro, would
Marshall EK. SCHEDULES OF ANTIBIOTIC ADMINISTRATION. JAMA. 1951;146(11):1062–1063. doi:10.1001/jama.1951.03670110082031