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August 4, 1951


JAMA. 1951;146(14):1326. doi:10.1001/jama.1951.03670140052013

Essential hypertension is believed to be of multiple etiology, involving neurogenic, cardiovascular, endocrine, and renal factors. Binet and Burstein1 demonstrated that centripetal stimulation of the vagus in a dog introduces into the blood of the animal a vasoconstrictor substance which is manifested by a rise in pressure in the blood vessels of the denervated leg of the dog perfused with its own blood or blood from another dog. Injection of "prosympal," or 883F (diethylamino-methyl-3-benzodioxane), a synthetic sympathicolytic drug, did not reverse the peripheral vasoconstriction in the same dog. They argued that, if the rise in pressure following centripetal stimulation of the vagus depended solely on discharge of epinephrine, the increased pressure in the blood vessels of the denervated leg should have been abolished by the action of the sympathicolytic drug. This irreversibility of the peripheral constriction by a sympathicolytic drug demonstrates the presence of a vasopressor substance of cerebral

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