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August 4, 1951

An Introduction to Universal Serologic Reaction in Health and Disease.

JAMA. 1951;146(14):1360. doi:10.1001/jama.1951.03670140086030

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In this monograph Dr. Kahn gives an account about his investigations on serologic reactions with lipid antigen. It is an important collaborative study originated as an attempt to prove "that the reaction between tissue extract antigen and serum might not be primarily a syphilis reaction." It is based on "an inherent biologic tendency for serum to react with antigen—a tendency which is unrelated to syphilis." By using a multiple quantitative precipitation system each of a different sodium chloride concentration, Dr. Kahn found that all human beings and many animals give positive precipitation reactions "differentiated from one another by serologic patterns which are based on the degree and arrangement of precipitation" in the various reacting zones. Therefore, the term "universal serologic reaction" appears justified. Various diseases other than syphilis (tuberculosis, yaws, leprosy, malaria) showed definite changes in serologic patterns.

The volume is clearly written by a distinguished author of high reputation.

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