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September 8, 1951


Author Affiliations

156 E. 79th St., New York 21.

JAMA. 1951;147(2):182. doi:10.1001/jama.1951.03670190082025

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To the Editor:  —The reason for the experience of Drs. Slotnik and Teigland (Cardiac Accidents Following Vasopressin Injection [Pitressin®], J. A. M. A. 146:1126 [July 21] 1951) can be sought in the fact that 20 units of pitressin® were injected. We regard it as a better policy to follow the advice of Goodman and Gilman, who in their textbook "The Pharmacological Basis of Therapeutics" recommend doses of 5 to 10 units to achieve the desired effect on the intestines.The danger of excessive doses of this substance lies not only in the possibility of creating disturbances of the coronary circulation. I saw Cheyne Stokes respiration after administration of a postpituitary extract, and I witnessed the reaction of an infant who received 5 units. A prolonged period of apnea with deep cyanosis and unconsciousness left a lasting impression which one would not wish to invite again.If a dose of pitressin®

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