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October 13, 1951

PHEOCHROMOCYTOMACASE REPORT WITH DISCUSSION OF DIFFERENTIAL DIAGNOSIS AND SURGICAL TREATMENT

Author Affiliations

Baltimore

From the Hospital for the Women of Maryland.

JAMA. 1951;147(7):642-645. doi:10.1001/jama.1951.73670240006006c
Abstract

Until recently pheochromocytoma has been considered a rare tumor of the chromaffin cells of the adrenal or other chromaffin tissue, of importance only as a medical curiosity. The increasing number of reported cases of successful surgical removal of these tumors emphasizes the fact that this condition should be considered in the differential diagnosis of diabetes, hyperthyroidism, and hypertension.1 When these three diseases coexist, pheochromocytoma must be ruled out carefully. The fact that it is most often diagnosed at autopsy2 indicates that more attention must be focused on this extremely interesting epinephrine-producing tumor.

Bartels and Cattell,3 in their recent article, emphasize the need for specific tests to aid in this difficult diagnosis. Our case also indicates that reactions to the histamine and piperoxan (benzodioxane) tests are not always positive in the presence of this type of tumor. The dibenamine® (N, N-dibenzyl betachloroethylamine hydrochloride) test was by far the

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