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November 3, 1951

EXPERIMENTAL BULBAR POLIOMYELITIS

JAMA. 1951;147(10):981. doi:10.1001/jama.1951.03670270071021
Abstract

It was estimated by Aycock1 that 70% of all cases of poliomyelitis occurring within 30 days after tonsillectomy are of the bulbar type. Attempts to reproduce post-tonsillectomy bulbar paralysis in monkeys, however, have nearly always failed, paralysis when produced usually being of the spinal type.2

Faber3 and associates of Standard University call attention to a possible error in the technic of these experiments. Exposure of the throat to the virus was invariably made after, rather than before, the operation. At this time the central cut ends of the local nerves were presumably sealed off with blood. They therefore repeated the experiments on monkeys, placing the virus on the pharyngeal surface before tonsillectomy.

The tests were made on cynomolgus monkeys, previously prepared by division of the olfactory tracts so as to preclude entry of the infection through the olfactory nerves. A 17% suspension of the Wis '45 strain

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