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November 24, 1951

RECURRENT THROMBOPHLEBITIS IN OBSCURE MALIGNANT TUMOR OF THE LUNGREPORT OF FOUR CASES

Author Affiliations

New York; Brooklyn, N. Y.

From the Medical Service of Dr. Joseph G. Terrence and Chest Surgical Service of Dr. Lew A. Hochberg, of Kings County Hospital, Brooklyn, N. Y.

JAMA. 1951;147(13):1213-1216. doi:10.1001/jama.1951.03670300027005
Abstract

In a review of the literature on thrombophlebitis it was noted that Trousseau1 observed that recurrent phlebitis may be the first sign that obscure carcinoma of a visceral organ is present. He attached diagnostic significance to the occurrence of thrombosis in cancer, demonstrating instances of latent cancer of the stomach in which peripheral venous thrombosis was the first symptom to attract attention, as indeed it was in Trousseau himself, who died of gastric cancer. Gouget2 reported a case of widespread venous thrombosis of eight months' duration; it was the only affection observed during the patient's life, but at necropsy a small gastric cancer was found. Osler and McCrae3 observed absence of gastric symptoms and 15 different thrombosed veins in a latent case of gastric carcinoma with profound and progressive anemia. Welch4 in his review emphasized that thrombosis is a recognized complication particularly associated with cancer. He

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