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December 1, 1951

INSECTICIDE STORAGE IN ADIPOSE TISSUE

Author Affiliations

Professor of Pharmacology Medical College of Virginia Richmond, Va.

JAMA. 1951;147(14):1381. doi:10.1001/jama.1951.03670310071030

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Abstract

To the Editor:  —In the editorial "Insecticide Storage in Adipose Tissue" published in The Journal (145:735 [March 10] 1951), there are two points to which I would like to call your attention.The statement is made: "Dichlorodiphenyldichloroethane, another analog, is stored in body fat to an even greater extent than dichlorodiphenyltrichloroethane,9 but its chronic effect is only half that of dichlorodiphenyltrichloroethane."In supporting reference 9 of the editorial, it is not stated that dichlorodiphenyldichloroethane is stored to a greater extent than dichlorodiphenyltrichloroethane, the only statement bearing on dichlorodiphenyldichloroethane storage reading: "DDD also accumulated in fatty tissues." On the basis of our own studies (Proc. Soc. Exper. Biol. & Med. 72:357, 1949) and those of Laug, Nelson, Fitzhugh, and Kunze (J. Pharmacol. & Exper. Therap. 98:268, 1950), both of these compounds are stored in fat to a similar degree, with the difference that dichlorodiphenyldichloroethane (DDD) is more

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