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February 9, 1952


Author Affiliations

Sterling-Winthrop Research Institute Rensselaer, N. Y.

JAMA. 1952;148(6):490. doi:10.1001/jama.1952.02930060072024

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To the Editor:—  Giarman, Flick, and White in "Prolongation of Thiopental Anesthesia in the Mouse by Premedication with Tetraethylthiuram Disulfide (`Antabuse')" (Science114:35 [July 13] 1951) show that premedication of mice with antabuse® markedly potentiates the effect of thiopental (pentothal®) sodium, the anesthesia time being increased sixtyfold. Graham, Carmichael, and Allmark in The in Vivo Potentiation of Barbiturates by Tetraethylthiuram Disulfide (J. Pharm. & Pharmacol. 3:497 [Aug.] 1951) demonstrate a similar effect in rats and guinea pigs, with sodium cyclural (hexobarbital sodium, evipal® soluble) and sodium phenobarbitone (sodium phenobarbital, luminal® sodium). The sleeping time was approximately doubled.Although, so far as the writer is aware, the potentiation of barbiturates in man by antabuse® has not been recorded, it is evident that, until data on this point are available, great caution should be observed in permitting the use of barbiturates in persons treated with antabuse.® The effects on such

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