March 1, 1952


JAMA. 1952;148(9):746-747. doi:10.1001/jama.1952.02930090056016

Debré and his associates1 reported in 1950, under the title "La maladie des griffes de chat," a hitherto undescribed clinical entity. The disease was seen most frequently in children and occasionally in adults. It was characterized by subacute lymphadenitis which frequently suppurated and healed without a scar. The course of the disease was usually mild but occasionally, particularly in adults, was accompanied by mild fever and painful adenopathy. The adenopathy was usually preceded by a small maculovesicular skin lesion. The patients often had a history of being scratched by a cat. Microscopic studies of the involved lymph node revealed formation of nodules composed of reticular cells and of a central necrosis. Attempts at identifying the causative agent have been unsuccessful. The infection apparently was not caused by bacteria or spirochetes, nor did it appear to be an anomalous type of tularemia or of lymphogranuloma venereum, both of which it

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