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To the Editor:—
The recent article "Influence of Some Drugs and of Emotions on Blood Coagulations," by Dr. D. I. Macht, in The Journal (148:265 [Jan. 26] 1952) ascribes to several common drugs an important influence in increasing blood coagulability and associates this effect with thrombotic and embolic episodes in patients receiving these drugs. Some negative views were cited but a more reliable conclusion would be reached if still others, such as the following, were examined. Sutton, Levin and Ruskin, Sokoloff and Ferrer, Moses, Poindexter and Meyers, and Fowler have examined the possible effect of digitaloids on the blood clotting mechanism in patients. Each of these studies demonstrated that the usual variations in such factors as clotting time and prothrombin time are not significantly changed after digitalization. Similarly, Fahey found that corticotropin and cortisone had no significant effect on coagulability of whole blood in patients with and without adrenal
Walton RP. BLOOD COAGULATION. JAMA. 1952;148(10):864. doi:10.1001/jama.1952.02930100082028