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March 8, 1952

Immuno-Catalysis and Related Fields of Bacteriology and Biochemistry

JAMA. 1952;148(10):876. doi:10.1001/jama.1952.02930100094036

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Interrelationships between phenomena of immunity and biocatalysis have been noted for some years. In fact, Ehrlich derived his famous lock and key simile for the expression of the specificity of antibody with respect to antigen from enzyme specificity studies of Emil Fischer. In general, however, workers in the field of enzymology have given little, if any, consideration to the possible relations among the fields of biochemistry, immunology, and bacteriology. The fullness of integration among these fields is indicated for the first time in this text. Specialists in either enzymology or immunology will consider the first three sections of this book to be a reservoir of experimental facts, considered with insight and interrelated with remarkable synthesis. The pharmacologically active enzymes indigenous to plants, pathogenic bacteria, and snake venoms are considered in detail, with references to the relation between their chemical activities in vitro and their pharmacodynamic actions in vivo. The production

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