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To the Editor:—
"Krebiozen," a substance obtained from the serum of treated horses, has been reported as possessing possible therapeutic value for human malignant tumors (Ivy, A. C., and others: Krebiozen: An Agent for the Treatment of Malignant Tumors, Chicago, Champlin-Shealy Co., 1951, pp. 1-106). The tests also indicated that it had no effect on a spontaneously occurring carcinoma in C3H mice nor on several transplanted tumors, including the C3HBA mammary carcinoma in C3H mice and the Jensen and Walker tumors in rats. No experimental details were given in the original publication, and, although a number of communications have since appeared (A Status Report on "Krebiozen," report of the Council on Pharmacy and Chemistry, J. A. M. A.147:864-873 [Oct. 27] 1951. Ivy, A. C.: Krebiozen, Science114:286, 1951. Rhoads, C. P.: Krebiozen, ibid. 114:285-286, 1951) no detailed reports concerning the effect of "krebiozen" on mouse neoplasms
Loefer JB. INEFFECTIVENESS OF "KREBIOZEN" THERAPY ON TRANSPLANTED MOUSE LEUKEMIA AND LYMPHOSARCOMA. JAMA. 1952;149(3):298. doi:10.1001/jama.1952.02930200084024