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Article
July 19, 1952

PHARMACOLOGIC PROPERTIES OF TOXAPHENE, A CHLORINATED HYDROCARBON INSECTICIDE

JAMA. 1952;149(12):1135-1137. doi:10.1001/jama.1952.72930290007015

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Abstract

Toxaphene is the accepted common name for a polychlor bicyclic terpene with insecticidal properties. It may be more properly identified as a chlorinated camphene with the average empirical formula C10H10Cl8. The structural formula has not been definitely established since the chlorination of camphene may involve the addition or substitution of chlorine, a rearrangement of the molecule, or a combination of these reactions.

The technical or insecticidal grade is an amber-colored, waxy solid with a mild pine-like odor. It contains 67 to 69% chlorine and melts in the range 70 to 95 C. Although insoluble in water, toxaphene is readily soluble in inexpensive commercial solvents, especially those of an aromatic hydrocarbon nature. It is practically nonvolatile and has residual properties resembling those of DDT (dichloro-diphenyl-trichloro-ethane). Like other chlorinated hydrocarbons of this type, toxaphene slowly evolves hydrochloric acid when heated, the rate depending upon temperature and the

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