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Article
July 19, 1952

BLOOD TRANSFUSION IN IRRADIATION HEMORRHAGE

JAMA. 1952;149(12):1142-1143. doi:10.1001/jama.1952.02930290064017
Abstract

The threat of atomic warfare and the ever-increasing peacetime exploitation of atomic energy have focused attention on the necessity for developing methods for the control or prevention of irradiation injury in man. The mortality in animals exposed to high levels of irradiation has been reduced by the administration of the broad spectrum antibiotics,1 by early exchange transfusion,2 by parabiosis,3 or by the implantation of fresh splenic tissue or the injection of spleen homogenates.4 In contrast, while the use of frequent whole blood transfusions would seem a logical method of combating the thrombocytopenia and anemia in the abnormal bleeding syndrome of irradiation sickness, Allen and his associates have shown that in dogs such transfusions not only are ineffective but may in some instances actually be harmful.5 The University of Chicago investigators exposed 173 dogs to single doses of total body x-radiation at dosage levels ranging from

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