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September 4, 1954

EVALUATION OF RED CROSS GAMMA GLOBULIN AS A PROPHYLACTIC AGENT FOR POLIOMYELITIS5. REANALYSIS OF RESULTS BASED ON LABORATORY-CONFIRMED CASES

Author Affiliations

Pittsburgh; Camden, N. J.; Pittsburgh; Camden, N. J.; Philadelphia; Pittsburgh; Baltimore

From the Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh (Dr. Hammon, Professor and Head of Department, Drs. Ludwig and Wehrle, Miss Sather), Camden Municipal Hospital for Contagious Diseases and Department of Pediatrics, School of Medicine, University of Pennsylvania (Drs. Coriell and McAllister) and Research Department, Children's Hospital of Philadelphia (Dr. Greene).; Dr. Wehrle is now at the Poliomyelitis Research Center, School of Hygiene and Public Health, Johns Hopkins University.

JAMA. 1954;156(1):21-27. doi:10.1001/jama.1954.02950010023009
Abstract

In previous reports1 we presented an analysis of the findings of a controlled field study2 on the prevention of paralytic poliomyelitis by gamma globulin. The diagnosis of the cases included in these earlier reports was based entirely on rigid clinical criteria previously outlined,2a since no laboratory data were available at that time. The accuracy of such criteria has never been completely evaluated, because suitable laboratory tests have only recently become available, but errors in etiological diagnosis were to be expected even though only paralytic cases were included. In this paper we are presenting a reanalysis of results based exclusively on laboratoryconfirmed cases. We shall also make reference to the United States Public Health Service reports3 concerning the general use of gamma globulin in 1953 as they relate to data from our controlled study.

LABORATORY METHODS  Infection with poliomyelitis virus can be determined by either of two

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