September 6, 1952


JAMA. 1952;150(1):49. doi:10.1001/jama.1952.03680010055017

Treatment of Pulmonary Tuberculosis with Isonicotinic Acid Hydrazid.  —Up to now Danish experiences with isonicotinic acid hydrazid (isoniazid) have not been so encouraging as those first reported from the United States. Since the middle of March 1952, it has been given a trial at the tuberculosis department of the Øresund Hospital, where Dr. Kjeld Tørning and Dr. Jørgen Haarhø have reported on the first 31 patients treated with it from one to two months. The drug was given in tablet form three times a day with meals at the rate of about 4 mg. per kilogram of body weight. With only three exceptions, these patients had already been given streptomycin and p-aminosalicylic acid, to both of which 10 of them had been found to be resistant. All the cases were bacillary, and about half of them were more or less febrile. The effect on appetite and weight was very

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