The influence of certain diseases on the clotting mechanism, especially in regard to the predisposition to bleeding and thrombosis, has attracted investigators. Allen and his co-workers1 have been interested in the bleeding tendency accompanying such conditions as thrombocytopenia and have proposed the protamine titration test to detect an increase in heparin-like substances in the blood. Rosenthal2 studied the blood of patients with polycythemia and leukemia with a battery of clotting procedures in an attempt to clarify the differences. He then modified the heparin retardation test. In addition, the Waugh-Ruddick test,3 the heparin tolerance test,4 the sensitized heparin clotting test,5 and others6 have been proposed and used to elucidate the causes or, at least, to anticipate the tendency to bleed or to clot abnormally.
Because of the pitfalls and vagaries of the clotting tests, we have performed a battery of these procedures on the blood
Friedman IA, Schwartz SO, Vincenti M. SURVEY OF CLOTTING TESTS FOR COAGULATION PROFILE IN NORMAL AND DISEASED PERSONS. JAMA. 1952;150(2):83-86. doi:10.1001/jama.1952.03680020017005