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September 13, 1952


JAMA. 1952;150(2):152. doi:10.1001/jama.1952.03680020086019

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Society for Renal Pathology.  —The Society for Renal Pathology heard a statement by P. P. Lambert, F. R. Grégoire, and associates (Brussels), on the action of corticotropin on glomerular permeability. They reported that in certain patients with nephrosis corticotropin reduces abluminuria. In an experimental study on dogs, the authors found that the ability of the animals' kidneys to filter hemoglobin is 5% as great as the ability to filter water and that this ratio is diversely influenced by corticotropin: increasing in 5 cases, decreasing in 2, and remaining within the limits of normal variation in 11. They observed that the effect of corticotropin on the excretion of hemoglobin follows the same pattern in dogs as in nephrotic patients; excretion increases after a short course of corticotropin treatment and decreases after a long one. The study of this question is intricate, as it would appear that corticotropin is influencing several factors

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