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October 4, 1952


Author Affiliations

Los Angeles
From the Department of Medicine, School of Medicine, University of California Medical Center, and the General Medical and Surgical Hospital, Veterans Administration Center.

JAMA. 1952;150(5):454-460. doi:10.1001/jama.1952.03680050020006

It is the purpose of this presentation to call attention to some of the significant changes that occur in the white blood cells in certain clinical disorders. The variations under consideration are numerical, morphological, and histochemical. It should be clearly understood that we feel the general clinical picture is much more important in diseased conditions than variations that may occur in the white blood cells. These changes constitute only one component of the total data. We have been concerned, at times, with the tremendous emphasis given to white blood cells in the interpretation and diagnosis of pathological states. While it is true that variations may be found in the white blood cell picture in many clinical disorders, it is equally true that knowledge of the white blood cell findings is not necessary in order to establish a diagnosis in the majority of them.

Further, erroneous diagnoses may result from placing

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