• Eighty-five patients manifested skin eruptions while being treated with chlorpromazine. While 57 of these had generalized reactions, almost all types of cutaneous eruptions occurred, with the exception of mucous membrane involvement. Dosage in these cases averaged 400 mg. or more a day. The lesions disappeared when the dosage was decreased or discontinued.
Patch tests indicate chlorpromazine to be a primary irritant when applied full strength and may be of little value in determining potential reactors to systemic administration of the drug.
Mullins JF, Cohen IM, Farrington ES. CUTANEOUS SENSITIVITY REACTIONS TO CHLORPROMAZINE. JAMA. 1956;162(10):946–948. doi:10.1001/jama.1956.02970270006002