• The effects of Frenquel were studied in 100 psychotic patients. Symptoms proved to be more useful than etiology in classifying the results, and many disturbed patients were quieted regardless of the accepted diagnosis. Improvement, if it occurred, was unequivocal and convincing. Twenty-two of the psychotic patients, for instance, were classified as subacutely disturbed, and 13 of these were definitely improved. Among 20 psychotic patients with subacute conditions classified as quiet, however, there was improvement only in six. The highest percentage of successes was among 11 acutely psychotic patients, 8 of whom were definitely improved. Many of the patients received 100 mg. of the drug intravenously in the beginning and continued receiving from 80 to 180 mg. daily in divided doses by mouth, but as a rule the dosage was 40 mg. by mouth four times a day. Six case histories are given to illustrate the uses of Frenquel. It did not manifest specific anti-hallucinatory properties, did not produce the immobilization that can be obtained with chlorpromazine or reserpine, and did not afford good control of anxiety in the nonpsychotic patient. Its greatest value was in controlling the hyperactive, acutely disturbed patients whose usual emotional defenses are in process of breaking down. In such patients it can be used over longer periods of time, for it proved to be singularly free from side-effects.
Cohen S, Parlour RR. PRELIMINARY OBSERVATIONS ON USE OF FRENQUEL IN HOSPITAL PSYCHIATRY. JAMA. 1956;162(10):948–950. doi:10.1001/jama.1956.02970270008003