• The diagnosis of eosinophilic granuloma of bone was made in five cases here reported; in each there was a circumscribed area of swelling or tenderness on a cranial bone, a characteristic circumscribed lytic lesion in the roentgenograms, and confirmation by microscopic examination of tissue obtained at operation. Headache attributable to extension of the tumor along meningeal blood vessels was severe in one case and present in two others; the intracranial pressure was normal and the neurological findings were negative in all cases. Surgical removal and subsequent irradiation to a total of 600 to 2,000 r in air was followed by healing and complete relief of symptoms. Eosinophilic granuloma should be considered as a diagnostic possibility whenever a patient presents a localized tenderness of the scalp or a lytic lesion of the skull.
Knighton RS, Fox JD. DIAGNOSIS AND TREATMENT OF EOSINOPHILIC GRANULOMA OF SKULL. JAMA. 1956;162(14):1294–1297. doi:10.1001/jama.1956.02970310022005