May 19, 1956


JAMA. 1956;161(3):240. doi:10.1001/jama.1956.02970030058013

Although the presence or absence of hydrochloric acid in gastric contents in certain patients has diagnostic importance, gastric analysis is not carried out in many of these patients for one or more of the following reasons: lack of information concerning the procedure or the information that might be derived, reluctance of the patient to swallow the tube, or lack of trained personnel to perform the test. In 1950, Segal, Miller, and Morton 1 described a method for determining the presence or absence of free gastric acidity without the use of intubation. This technique consisted of feeding the patient an ionexchange resin that was coupled with quinine. If there was free hydrochloric acid in the stomach the quinine was freed from the resin and then absorbed by the intestine. After absorption the quinine was excreted in the urine, from which it could be readily extracted with an organic solvent. Its presence

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