• Estrogens were compared with androgens as to their effects on 133 patients with advanced mammary cancer. Estrogens should not be used for this purpose in women less than five years past the menopause; when properly used they were found to be somewhat superior to the androgens in their objective effects on lesions in soft tissues and viscera. The androgens were somewhat more potent by subjective critera. Both androgens and estrogens gave a sense of well-being and partial or complete relief of pain in about half of the patients. Regression of the tumor sometimes occurs also upon discontinuation of hormone therapy that has been ineffective or has ceased to maintain an initial improvement. Full use should be made of these profound and gratifying palliative effects of hormone therapy.
Lewison EF, Trimble FH, Ganelin RS. ADVANCED MAMMARY CANCER TREATED WITH SEX HORMONES. JAMA. 1956;162(16):1429-1437. doi:10.1001/jama.1956.02970330001001