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Article
December 15, 1956

THE DETERMINATION AND CLINICAL VALUE OF UROPEPSINOGEN

Author Affiliations

Philadelphia

Fellow, National Institute of Arthritis and Metabolic Diseases (Dr. Peak); Chemist to the Pennsylvania Hospital (Dr. Viergiver); Assistant Section Head, Biochemistry, Smith, Kline & French Laboratories (Dr. Van Loon); and Director of the medical divisions of the Pennsylvania Hospital and the Benjamin Franklin Clinic (Dr. Duncan). Dr. Peak is now in Louisville, Ky.

JAMA. 1956;162(16):1441-1444. doi:10.1001/jama.1956.02970330013003
Abstract

• Determination of the concentration of pepsinogen in the urine can be technically practical and clinically useful. It may offer a better index of gastric peptic activity than does intubation, and it has been useful in the differential diagnosis of peptic ulcer versus gastric carcinoma. Uropepsinogen values can aid in locating the site of hematemesis and can assist in the diagnosis of pernicious anemia. The response of uropepsinogen to hormone stimulation may provide many diagnostic, as well as therapeutic, indexes to endocrinological conditions.

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