• Determination of the concentration of pepsinogen in the urine can be technically practical and clinically useful. It may offer a better index of gastric peptic activity than does intubation, and it has been useful in the differential diagnosis of peptic ulcer versus gastric carcinoma. Uropepsinogen values can aid in locating the site of hematemesis and can assist in the diagnosis of pernicious anemia. The response of uropepsinogen to hormone stimulation may provide many diagnostic, as well as therapeutic, indexes to endocrinological conditions.
Peak WP, Viergiver E, Van Loon EJ, Duncan GG. THE DETERMINATION AND CLINICAL VALUE OF UROPEPSINOGEN. JAMA. 1956;162(16):1441–1444. doi:10.1001/jama.1956.02970330013003