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November 1, 1952


Author Affiliations

Ved Damhussøen 16, Vanløse, Copenhagen, Denmark

JAMA. 1952;150(9):951. doi:10.1001/jama.1952.03680090115022

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To the Editor:  —In The Journal, Aug. 9, 1952, page 1399, there is a report of congenital thyroid hyperplasia in twins whose mother was treated with thiouracil and iodine during pregnancy. Apparently, the authors do not know about similar cases reported in the literature. In most cases of pregnancy complicated by hyperthyroidism in which the patient has been treated with thiouracil no effect of this drug has been demonstrated on the child (Astwood: J. Clin. Endocrinol.11:1045, 1951). The following cases, however, have been reported.Eaton (Lancet1:171, 1945) has seen a child with congenital goiter, which disappeared within three months. Davis and Forbes report the autopsy of a 6-month-old fetus, with a hyperplastic thyroid gland. The histological examination indicated considerable functional activity. Freiesleben and Kjerulf-Jensen (J. Clin. Endocrinol.7:47, 1947) have demonstrated thyroid hyperplasia in a 5-month-old fetus. Frisk and Josefsson (Acta med. scandinav., suppl. 196,

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