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November 8, 1952

ANTICANCER THERAPY

JAMA. 1952;150(10):1017. doi:10.1001/jama.1952.03680100059019
Abstract

Crossley1 and associates of the Bureau of Biological Research, Rutgers University, have reported interesting results of animal experiments on the chemotherapy of cancer. In earlier work Crossley had shown that treatment of rats bearing transplanted sarcoma 231 with adequate doses of triethylene melamine (2,4,6,-triethylenimino-s-triazine, TEM) or related products results in a complete regression of the sarcoma. Convalescent rats were resistant to further transplants of the same sarcoma. Crossley has recently repeated the therapeutic tests on rats bearing transplanted carcinomas.

In a typical test eight male rats averaging 140 gm. in weight were implanted with the Flexner-Jobling carcinoma. Four of them served as untreated controls. Beginning on the eighth day the other four were treated with 0.057 mg. per kilogram of body weight of TEM given four times daily intraperitoneally. Reversal of tumor growth was noted in all four rats on the third day of treatment and continued to complete

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