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November 8, 1952


JAMA. 1952;150(10):1033. doi:10.1001/jama.1952.03680100075027

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New Test for Diagnosis of Cancer of Prostate.  —The techniques in current use for measuring the activity of serum acid phosphatases, based on the hydrolysis of orthophosphoric monoesters such as β-glycerophosphate under the action of serum, have proved deceiving. A. Desjobert, C. Anagnostopoulos, and A. Recoules propose to determine whether the high phosphatasic acid activity of a serum is a result of the presence, in this serum, of phosphatase of prostatic origin. They used morpholinoethylphosphate as a substrate. Titrations were parallelly effected with β-glycerophosphate and with morpholinoethylphosphate by Courtois and Plumel's technique. The activity of phosphatase was evaluated by determining the ratio between the phosphorus (in milligrams) liberated from morpholinoethylphosphate and the phosphorus (in milligrams) liberated from β-glycerophosphate. Although this technique alone does not constitute a means of diagnosing cancer of the prostate, it furnishes the clinician with some information. The authors are pursuing their researches.

Chickenpox and Herpes Zoster. 

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