• Meprobamate is remotely related to mephenesin. This latter drug has been used successfully to relieve muscle stiffness, although rather large doses were required. Meprobamate also has a muscle-relaxing effect on voluntary skeletal muscle, in addition to its apparent tranquilizing action; but it is possible that the relief of tension may be the direct result of muscle relaxation. With a dosage of 400 mg. of meprobamate three or four times a day, relief of muscle stiffness and pain was achieved in 83.3% of 252 patients. The most common side-effect was drowsiness, which disappeared in many cases, though the dosage remained the same, and was relieved in others by lowering the dosage. Meprobamate was also useful in combating the overstimulation of steroid therapy.
Smith RT, Hermann IF, Kron KM, Peak WP. MEPROBAMATE (MILTOWN) IN RHEUMATIC DISEASES. JAMA. 1957;163(7):535-538. doi:10.1001/jama.1957.02970420017006