• Chlorpromazine was injected intramuscularly in 25-mg. or 50-mg. doses as premedication for anesthesia in 725 surgical patients. In 155 of these it was given 90 minutes before induction, and an interval of 30 minutes was allowed to elapse before supplementary premedication with scopolamine and either morphine or meperidine. The most frequent complications ascribed to the chlorpromazine were hypotension and tachycardia.
Chlorpromazine was believed to have contributed to ease of induction and maintenance of a satisfactory physiological state in this study. Its use is not recommended in patients with abnormally high, low, or labile blood pressure, with evidence of liver disease, or with conditions rendering them liable to hemodynamic upsets.
Weiss WA, McGee JP, Hanks EC. VALUE OF CHLORPROMAZINE IN PREOPERATIVE MEDICATION. JAMA. 1956;161(9):812–815. doi:10.1001/jama.1956.02970090038008